1: methanol With thionyl chloride T=0 - 5°C; 2: (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid in ethanol T=40 - 45°C; 6 - 12 h; 3: With water; sodium carbonate pH=6.5;

1: With methanesulfonic acid in acetonitrile T=20 - 45°C; 1 h; 2: With sodium carbonate in isopropanol acetate; water T=5 - 20°C; pH=8.5; Product distribution / selectivity;

thionyl chloride in acetonitrile T=0 - 20°C; 24.5 h; Product distribution / selectivity;

sodium carbonate in tert-butyl methyl ether; water pH=9.6; 1.5 h; Product distribution / selectivity;

in ethanol; isopropanol acetate T=20 - 60°C; 15 h;