1: methanol With thionyl chloride T=0 - 5°C; 2: (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid in ethanol T=40 - 45°C; 6 - 12 h; 3: With water; sodium carbonate pH=6.5;