1-beta-D-阿拉伯糖呋喃基胞嘧啶 5'-二磷酸酯-1-O-十八烷基-2-O-棕榈酰-甘油合成路线 （共 6 条）
反应条件
1: pyridine / benzene / 70 °C 2: hydrogen, HOAc / 10percent Pd/C / hexane / 72 h / 2585.7 Torr 3: 45 percent / POCl3, Et3N / hexane; toluene / 18 h / Ambient temperature 4: 29 percent / pyridine / 120 h / Ambient temperature View Scheme
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
反应条件
1: NaNH2 / toluene / Heating 2: pyridine / benzene / 70 °C 3: hydrogen, HOAc / 10percent Pd/C / hexane / 72 h / 2585.7 Torr 4: 45 percent / POCl3, Et3N / hexane; toluene / 18 h / Ambient temperature 5: 29 percent / pyridine / 120 h / Ambient temperature View Scheme
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
反应条件
1: pyridine / 24 h / Ambient temperature 2: pyridine / toluene / 24 h / Ambient temperature 3: BF3-2MeOH / CH2Cl2 / 0.5 h / 0 °C 4: 45 percent / POCl3, Et3N / hexane; toluene / 18 h / Ambient temperature 5: 29 percent / pyridine / 120 h / Ambient temperature View Scheme
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
反应条件
1: 45 percent / POCl3, Et3N / hexane; toluene / 18 h / Ambient temperature 2: 29 percent / pyridine / 120 h / Ambient temperature View Scheme
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
反应条件
1: pyridine / toluene / 24 h / Ambient temperature 2: BF3-2MeOH / CH2Cl2 / 0.5 h / 0 °C 3: 45 percent / POCl3, Et3N / hexane; toluene / 18 h / Ambient temperature 4: 29 percent / pyridine / 120 h / Ambient temperature View Scheme
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
反应条件
pyridine 120 h; Ambient temperature;
参考文献
Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044
