sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=10 - 20°C; Inert atmosphere;

ethylaluminum dichloride in hexane; toluene T=100°C; P=22502.3 Torr; 3 h; AutoclaveInert atmosphere; regioselective reaction;

sodium chloride in methanol; chloroform; isopropyl alcohol; acetone

1: 68 percent / aq. NaHCO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 6 h / Heating 2: 46 percent / Jones reagent / acetone / 18 h / 20 °C View Scheme

1: 68 percent / aq. NaHCO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 6 h / Heating 2: 46 percent / Jones reagent / acetone / 18 h / 20 °C View Scheme

1.1: tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 0.25 h / 20 °C / |Inert atmosphere 1.2: 6.5 h / 80 °C / |Inert atmosphere 2.1: dihydrogen peroxide; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 10 - 20 °C / |Inert atmosphere View Scheme

1.1: tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 0.25 h / 20 °C / |Inert atmosphere 1.2: 6.5 h / 80 °C / |Inert atmosphere 2.1: dihydrogen peroxide; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 10 - 20 °C / |Inert atmosphere View Scheme