[RuCl2(.eta.6-p-cymene)((R)-PhOP(binaphthoxy))]; potassium tert-butylate in tetrahydrofuran T=75°C; 1.5 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
1: ethyl bromide With iodine; magnesium in diethyl ether Inert atmosphere; 2: para-bromobenzonitrile in diethyl ether Grignard reaction; 6 h; Reflux; 3: With sulfuric acid; water in diethyl ether Heating;
参考文献
European Journal of Pharmaceutical Sciences, , vol. 43, # 5 p. 386 - 392
