sodium hydride in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
1: With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; 18 h; Heating / reflux;
2: With ammonium hydroxide in water; N,N-dimethyl-formamide; toluene
参考文献
MEDIVIR AB
Patent: WO2008/114054 A1, 2008 ;
Location in patent: Page/Page column 40 ;
Rosowsky, Andre; Wright, Joel E.; Vaidya, Chitra M.; Forsch, Ronald A.; Bader, Henry
Journal of Medicinal Chemistry, 2000 , vol. 43, # 8 p. 1620 - 1634
