triethylamine in N,N-dimethyl-formamide

CHIRALPAK.(R). AS-H in methanol; carbon dioxide; diethylamine T=35°C; P=75007.5 Torr; Resolution of racemate; Purification / work up;

CHIRALPAK.(R). AS-H in methanol; carbon dioxide; diethylamine T=35°C; P=75007.5 Torr; Resolution of racemate; Purification / work up;

1: 90 g / 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 0.25 h / pH = 9.5 2: HCl(g) / ethyl acetate / 0.5 h / 0 °C 3: 1) PhCNS; 2) CF3CO2H / 1) CH2Cl2, reflux, 20 min; 2) 50 deg C, 20 min View Scheme