1: 2-bromo-pyrimidine With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl in tetrahydrofuran T=-55°C; 1.5 h; Inert atmosphere; 2: methanethiosulfonic acid S-methyl ester in tetrahydrofuran T=-55 - 20°C; Inert atmosphere; regioselective reaction;