sodium hydroxide in water; toluene 8 h; Heating / reflux;

potassium 2-methyl-2-butoxide in N,N-dimethyl-formamide; toluene T=55 - 85°C; RefluxLarge scale;

<b>Multi-step reaction with 3 steps<br /> </b>1: triphenylphosphine; palladium diacetate; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 130 &deg;C / 3750.38 - 4500.45 Torr / |Autoclave; |Inert atmosphere; |Large scale<br />2: hydrogen; 5 Pd/C / methanol / 45 - 55 &deg;C / |Inert atmosphere; |Large scale<br />3: triethylamine; formaldehyd / isopropyl alcohol; water / 35 - 45 &deg;C / |Large scale<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635639', constants.ctx, '0')">isopropyl alcohol</a> <br />T=35 - 45&deg;C;&nbsp;2 - 6&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209228', constants.ctx, '0')">formaldehyd</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635639', constants.ctx, '0')">isopropyl alcohol</a> <br />T=35 - 45&deg;C;&nbsp;&nbsp;Large scale;&nbsp;<br /> &nbsp;