17-Beta-雌二醇 3-甲醚合成路线 （共 45 条）
反应条件
1: 91 percent / K2CO3 / acetone; CH2Cl2 / 5 h / Heating 2: 94 percent / NaBH4; MeOH / CH2Cl2 / 1 h / 50 °C View Scheme
参考文献
Steroids, , vol. 72, # 13 p. 892 - 900
反应条件
tetra-n-butylammonium tetrafluoroborate in tetrahydrofuran; water T=22 - 25°C; electroreduction;
参考文献
Kariv-Miller, Essie; Swenson, Karl E.; Lehman, Gaye K.; Andruzzi, Romano
Journal of Organic Chemistry, 1985 , vol. 50, # 5 p. 556 - 560
反应条件
ammonia; lithium; aniline in tetrahydrofuran 0.5 h;
参考文献
Bijoy, Panicker; Ramachandran, Uma; Rao, G. S. R. Subba
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 16 p. 2331 - 2334
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) -78 deg C to 4 deg C, 20 h, 2.) -78 deg C, 2.4 h;
参考文献
Steroids, , vol. 61, # 6 p. 349 - 353
反应条件
lithium aluminium tetrahydride; n-butyllithium in tetrahydrofuran 1.) -78 deg C to 4 deg C, 20 h, 2.) -78 deg C, 2.4 h;
参考文献
Steroids, , vol. 61, # 6 p. 349 - 353
反应条件
hydrogen; palladium on activated charcoal in ethanol 10 h; Ambient temperature;
参考文献
Zeitschrift fuer Chemie (Stuttgart, Germany), , vol. 23, # 11 p. 410 - 411
反应条件
potassium carbonate; sodium iodide in acetone T=0 - 20°C; Inert atmosphere;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 80, # 10 p. 2008 - 2010
反应条件
potassium hydroxide T=100°C;
参考文献
Journal of the Chemical Society, , p. 445,451
Biochemical Journal, , vol. 32, p. 641,644
反应条件
sec.-butyllithium; zinc(II) chloride 1.) cyclohexane, THF, -20 deg, 45 min, 2.) 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of the American Chemical Society, , vol. 102, # 15 p. 5004 - 5011
反应条件
1: 0.1 N (CH3)3CONa / diethyl ether; 2-methyl-propan-2-ol / 20 h / Ambient temperature 2: 61 percent / 10percent H2SO4 / methanol / 24 h / Ambient temperature 3: 1) mesitol, molecular sieve, 2) K, aniline / 1) pyridine, anh. methylcyclohexane, 10 h, irradiation, 2) liq. NH3 View Scheme
参考文献
, vol. No. 11, p. 1999 - 2040
