4-羟基-6-甲基-2-吡啶酮-3-羧酸乙酯合成路线 （共 13 条）
反应条件
sodium ethanolate in ethanol T=140 - 160°C; Cyclization; 17 h;
参考文献
Stadlbauer, Wolfgang; Fiala, Werner; Fischer, Michaela; Hojas, Gerhard
Advanced Synthesis and Catalysis, 2000 , vol. 342, # 1 p. 33 - 39
反应条件
1: 89 percent / POCl3 / 4 h / 140 °C 2: 76 percent / Na / 3 h / 60 °C 3: 74 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: 89 percent / POCl3 / 4 h / 140 °C 2: 83 percent / Na / 3 h / 60 °C View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: POCl3 / 130 °C 2: palladium; potassium acetate; ethanol / Hydrogenation 3: aqueous KOH View Scheme
参考文献
Kooyman; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 10,13
反应条件
hydrogenchloride T=195°C;
参考文献
Salemink; van der Want
Recueil des Travaux Chimiques des Pays-Bas, 1949 , vol. 68, p. 1013,1024
反应条件
1: With 1-[N,N-bis-(2-hydroxyethyl)amino]-2-propanol; trichlorophosphate T=0 - 25°C; 20 h; 2: With sodium carbonate in water T=0°C; pH=8;
参考文献
Pfizer Inc.
Patent: US2009/54395 A1, 2009 ;
Location in patent: Page/Page column 44 ;
反应条件
trichlorophosphate 1 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 9 p. 1329 - 1333
反应条件
trichlorophosphate T=130°C;
参考文献
Kooyman; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1946 , vol. 65, p. 10,13
反应条件
1: 89 percent / POCl3 / 4 h / 140 °C 2: 83 percent / Na / 3 h / 60 °C 3: 81 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 4: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
sulfuric acid; nitric acid
参考文献
Bruce; Perez-Medina
Journal of the American Chemical Society, 1947 , vol. 69, p. 2571,2573
Full Text Show Details
Klosa
Archiv der Pharmazie (Weinheim, Germany), 1952 , vol. 285, p. 453,457
