2-[(三甲基甲硅烷基)乙炔基]苯胺合成路线 （共 40 条）
反应条件
1: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=20°C; 5 h; 2: With water in tetrahydrofuran
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 63-64 ;
WO 2005/019184 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide T=20°C; Sonogashira reaction;
参考文献
Gonzalez-Gomez, Alvaro; Dominguez, Gema; Perez-Castells, Javier
European Journal of Organic Chemistry, 2009 , # 29 p. 5057 - 5062
反应条件
5 Au/Fe2O3; hydrogen in toluene T=60 - 120°C; P=750.075 - 15001.5 Torr; 2 h; Autoclave; chemoselective reaction;
参考文献
Yamane, Yoshihiro; Liu, Xiaohao; Hamasaki, Akiyuki; Ishida, Tamao; Haruta, Masatake; Yokoyama, Takushi; Tokunaga, Makoto
Organic Letters, 2009 , vol. 11, # 22 p. 5162 - 5165
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran T=20°C; Sonogashira Cross-Coupling; Inert atmosphereSealed tube;
参考文献
Organic Letters, , vol. 15, # 4 p. 840 - 843
反应条件
1: aq. K2CO3 / methanol / 24 h / 50 °C 2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: ICl / dimethylformamide / 0.5 h / 20 °C 2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
sulfuric acid in benzene T=80°C;
参考文献
Klumpp, Douglas A.; Rendy, Rendy; Zhang, Yun; McElrea, Aaron; Gomez, Alma; Dang, Han
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8108 - 8110
反应条件
trifluorormethanesulfonic acid T=80°C; 6 h;
参考文献
Klumpp, Douglas A.; Rendy, Rendy; Zhang, Yun; McElrea, Aaron; Gomez, Alma; Dang, Han
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8108 - 8110
反应条件
trifluorormethanesulfonic acid T=80°C; 6 h;
参考文献
Klumpp, Douglas A.; Rendy, Rendy; Zhang, Yun; McElrea, Aaron; Gomez, Alma; Dang, Han
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8108 - 8110
反应条件
1: pyridine / CH2Cl2 / 0 - 20 °C 2: K2CO3 / methanol / 3 h / 20 °C 3: 97 percent / diethyl zinc / toluene / 3 h / Heating View Scheme
参考文献
Yin, Yan; Ma, Wenying; Chai, Zhuo; Zhao, Gang
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5731 - 5736
