2-[(三甲基甲硅烷基)乙炔基]苯胺合成路线 （共 40 条）
反应条件
1: 91 percent / pyridine / 6 h / 20 °C
2: 85 percent / K2CO3 / methanol / 3 h / 20 °C
3: 87 percent / Cu(OAc)2 / 1,2-dichloro-ethane / 1.5 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Iwashita, Shigeki; Nagano, Tatsuo; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 4 p. 1305 - 1308
反应条件
1: 1.) NaNO2, conc. HCl, 2.) KI / 1.) H2O, 0 deg C, 50 min, 2.) H2O, room temp., overnight
2: 80 percent / aq. NaOH / ethanol; tetrahydrofuran / 0.5 h
View Scheme
参考文献
Lavastre, Olivier; Cabioch, Sandrine; Dixneuf, Pierre H.; Vohlidal, Jiri
Tetrahedron, 1997 , vol. 53, # 22 p. 7595 - 7604
反应条件
indium tribromide in methanol
24 h; Heating;
参考文献
Sakai, Norio; Annaka, Kimiyoshi; Fujita, Akiko; Sato, Asuka; Konakahara, Takeo
Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4160 - 4165
反应条件
1.1: NaNO2; 6N HCl / H2O / 0.5 h / 0 °C
1.2: 73 percent / 3 h / Heating
2.1: 77 percent / POCl3 / pyridine; chlorobenzene / 1 h / Heating
3.1: 86 percent / 2M K2CO3 / Pd(PPh3)4 / H2O; ethanol; 1,2-dimethoxy-ethane / 16 h / Heating
View Scheme
参考文献
Gautheron Chapoulaud; Ple; Turck; Queguiner
Tetrahedron, 2000 , vol. 56, # 30 p. 5499 - 5507
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C
2: potassium fluoride / N,N-dimethyl-formamide; water / 0.5 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); hydrogenchloride / tetrahydrofuran; water / 60 h / 45 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao
Organic Letters, 2014 , vol. 16, # 3 p. 948 - 951
反应条件
1: 0.940 g / KF/Al2O3 / 0.07 h / microwave irradiation (30 percent power)
2: 71 percent / Et3N / diethyl ether / 0 - 20 °C
View Scheme
参考文献
Liu, Gang; Xu, Guangyang; Li, Jian; Ding, Dong; Sun, Jiangtao
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1387 - 1390
反应条件
1: 88 percent / Et3N / diethyl ether / 1 h / 0 °C
2: 98 percent / KOH; Bu4NI / tetrahydrofuran / 5 h / sonication
View Scheme
参考文献
Dominguez, Gema; Casarrubios, Luis; Rodriguez-Noriega, Javier; Perez-Castells, Javier
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2856 - 2861
反应条件
1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 7 h / 25 °C
2: 75 percent / Cu(OAc)2; pyridine / methanol / 24 h / 25 °C
3: 87 percent / KH; NMP / 20 h / 80 °C
View Scheme
参考文献
Koradin, Christopher; Dohle, Wolfgang; Rodriguez, Alain L.; Schmid, Bertram; Knochel, Paul
Tetrahedron, 2003 , vol. 59, # 9 p. 1571 - 1587
反应条件
1: 1.) NaNO2, conc. HCl, 2.) KI / 1.) H2O, 0 deg C, 50 min, 2.) H2O, room temp., overnight
2: 73 percent / aq. NaOH / ethanol; tetrahydrofuran / 0.5 h
View Scheme
参考文献
Lavastre, Olivier; Cabioch, Sandrine; Dixneuf, Pierre H.; Vohlidal, Jiri
Tetrahedron, 1997 , vol. 53, # 22 p. 7595 - 7604
反应条件
1: 92 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C
2: 93 percent / CuI; PPh3; Et3N / PdCl2 / 14 h / 80 °C
3: 70 percent / KH / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C
View Scheme
参考文献
Koradin, Christopher; Dohle, Wolfgang; Rodriguez, Alain L.; Schmid, Bertram; Knochel, Paul
Tetrahedron, 2003 , vol. 59, # 9 p. 1571 - 1587
