potassium hydroxide in ethanol 48 h; Heating;

1: CH2Cl2 / 0.5 h / Ambient temperature 2: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C 3: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 4: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 5: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

2: CH2Cl2 / 0.5 h / Ambient temperature 3: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C 4: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 5: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 6: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

1: acetic anhydride / 2 h / 110 °C 2: CH2Cl2 / 0.5 h / Ambient temperature 3: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C 4: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 5: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 6: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

1: CH2Cl2 / 0.5 h / Ambient temperature 2: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C 3: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 4: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 5: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

1: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 2: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

1: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 2: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 3: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme

1: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C 2: 87 percent / KOH / tetrahydrofuran; H2O / 1.5 h / 65 - 70 °C 3: 90 percent / various solvent(s) / 18 h / 100 - 110 °C 4: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating View Scheme