(r)-氮丙啶-2-羧酸甲酯合成路线 (共 4 条)
反应条件
trifluoroacetic acid in methanol; chloroform
T=0°C; 2.5 h;
参考文献
Axelsson, B. Svante; O'Toole, Kevin J.; Spencer, Philip A.; Young, Douglas W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 7 p. 807 - 816
反应条件
triphenyl-phosphine oxide in acetonitrile
T=20°C; 24 h;
参考文献
Morieux, Pierre; Stables, James P.; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8968 - 8975
反应条件
1: (D)-serine methyl ester hydrochloride With triethylamine
2: Diethyloxytriphenylphosphorane
参考文献
Morieux, Pierre; Salome, Christophe; Park, Ki Duk; Stables, James P.; Kohn, Harold
Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5716 - 5726
反应条件
sodium chloride in water
24 h; Ambient temperatureCandida cylindracea lipase, potassium phosphate buffer (pH 7.5); Candida cyligracea lipase-catalysed hydrolysis of methyl aziridine-2-carboxylates and 2,3-dicarboxylates; enzymatic resolution; conversion, enantioselectivity, enantiomeric excess; Product distribution;
参考文献
Bucciarelli, Maria; Forni, Arrigo; Moretti, Irene; Prati, Fabio; Torre, Giovanni
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 23 p. 3041 - 3046