triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;

magnesium trifluoromethane sulfonate in toluene T=110°C; 15 h;

1: With copper(l) iodide; lithium tert-butylate in N,N-dimethyl-formamide; acetonitrile T=20°C; 0.0833333 h; Inert atmosphere; 2: in N,N-dimethyl-formamide; acetonitrile T=20°C; 24 h; Inert atmosphereIrradiation;

copper(l) iodide; di-tert-butyl peroxide; 4,7-Dimethoxy-1,10-phenanthroline in benzene T=100°C; 24 h; Inert atmosphere;

triethylamine in dichloromethane T=20°C; 1 h;

1: ethyl tribromoacetate; triphenylphosphine / CH2Cl2 / 3 h / 20 °C 2: Et3N / CH2Cl2 / 1 h / 20 °C View Scheme

in acetonitrile T=60°C; 2 h; Yield given;

1: With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: With triethylsilane in dichloromethane T=0 - 25°C; Inert atmosphere; 3: With citric acid in tetrahydrofuran; dichloromethane; water T=45°C; 2 h; chemoselective reaction;

1: With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: With triethylsilane in dichloromethane T=0 - 25°C; Inert atmosphere; 3: With diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=25°C; 12 h; Inert atmosphere; chemoselective reaction;