1: tributylamine salt of 2-(2-(4-chlorophenoxy)phenyl)acetic acid With hydrogenchloride in dichloromethane; water pH=1.5; 2: N-methylglycine methyl ester With dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0 - 15°C; 0.75 h;

triethylamine in N,N-dimethyl-formamide; toluene T=20°C; 2 h;

triethylamine in N,N-dimethyl-formamide; toluene T=5 - 20°C; 2.16667 h;

1.1: sulfuric acid / 1 h / Reflux 2.1: caesium carbonate / copper(l) chloride; N,N-dimethylaminoacetic acid / 1,4-dioxane / 110 - 115 °C 2.2: 5 h / 25 - 65 °C 3.1: hydrogenchloride / dichloromethane; water / pH 1.5 3.2: 0.75 h / 0 - 15 °C View Scheme

1.1: caesium carbonate / copper(l) chloride; N,N-dimethylaminoacetic acid / 1,4-dioxane / 110 - 115 °C 1.2: 5 h / 25 - 65 °C 2.1: hydrogenchloride / dichloromethane; water / pH 1.5 2.2: 0.75 h / 0 - 15 °C View Scheme

1.1: caesium carbonate / copper(l) chloride; glycine / 1,4-dioxane / 120 h / Reflux 1.2: pH 1 2.1: thionyl chloride / toluene / 1 h / 50 °C 3.1: triethylamine / N,N-dimethyl-formamide; toluene / 2.17 h / 5 - 20 °C View Scheme

1.1: caesium carbonate / copper(l) chloride; glycine / 1,4-dioxane / 120 h / Reflux 1.2: pH 1 2.1: thionyl chloride / toluene / 1 h / 50 °C 3.1: triethylamine / N,N-dimethyl-formamide; toluene / 2.17 h / 5 - 20 °C View Scheme

1: thionyl chloride / toluene / 1 h / 50 °C 2: triethylamine / N,N-dimethyl-formamide; toluene / 2.17 h / 5 - 20 °C View Scheme

1.1: potassium tert-butylate / toluene / 3 h / 20 °C 1.2: 3 h / 20 °C 2.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C 3.1: formic acid; iodine; magnesium / toluene; methanol / 5 h / 20 - 40 °C 3.2: 5 - 10 °C / pH ~ 1 4.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 20 °C 4.2: 6 h / Reflux 4.3: 10 - 15 °C 5.1: isopropyl alcohol / 13.75 h / -10 - 65 °C View Scheme

1.1: potassium tert-butylate / toluene / 3 h / 20 °C 1.2: 3 h / 20 °C 2.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C View Scheme