2-(2-(2-(4-氯苯氧基)苯基)-n-甲基乙酰氨基)乙酸甲酯合成路线 （共 11 条）
反应条件
1.1: potassium tert-butylate / toluene / 3 h / 20 °C 1.2: 3 h / 20 °C 2.1: phosphorous pentoxide; phosphoric acid / 96 h / 115 - 120 °C 3.1: formic acid; iodine; magnesium / toluene; methanol / 5 h / 20 - 40 °C 3.2: 5 - 10 °C / pH ~ 1 4.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 20 °C 4.2: 6 h / Reflux 4.3: 10 - 15 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; MADHU, Elevathingal Nicholas; SATYANARAYANA, Komati; SEETHA RAMA SARMA, Peri
Patent: WO2012/38975 A2, 2012 ;
