(R)-1-苯基-1,3-丙二醇合成路线 （共 39 条）
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Journal of Organic Chemistry, , vol. 67, # 20 p. 7080 - 7090
反应条件
1: tBuOOH; L-(+)-diethyl tartrate; Ti(OiPr)4 / CH2Cl2 / -20 °C 2: Red-Al / 1,2-dimethoxy-ethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 18 p. 4130 - 4135
反应条件
1: 95 percent / p-toluenesulfonic acid monohydrate / benzene / Heating 2: (4S)-4-benzyl-3-mesyl-2-phenyl-1,3,2-oxazaborolidin-5-one; dimethyl-(2-methyl-2-propenyl)phenylsilane / CH2Cl2 / 24 h / -50 °C 3: 1N HCl / ethanol / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 20 p. 7080 - 7090
反应条件
2: base 3: O3 / CH2Cl2 / -78 °C 4: NaBH4 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 51 p. 9253 - 9254
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 40, # 21 p. 4093 - 4096
反应条件
1.1: Et3N; MgCl2 2.1: NaBH4 / methanol; tetrahydrofuran / Heating 3.1: HMDS; TMSOTf 3.2: (-)-menthone; TMSOTf 3.3: HCl / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2178 - 2189
反应条件
1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1.1: 95 percent / NaI; Et3N 2.1: 80 percent / SiCl4; (R,R)-bis-phosphoramide; i-Pr2NEt / CH2Cl2 / 24 h / -50 °C 3.1: O3 3.2: 71 percent / LiAlH4 View Scheme
参考文献
Synlett, , # 13 p. 2411 - 2416
反应条件
1: lithium cumene peroxide; 1R,2R-[2-(2-methoxyphenoxy)-1,2-diphenylethyl]dimethylamine / toluene / 36 h / 0 °C 2: 22 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 25 p. 4549 - 4556
