(R)-1-苯基-1,3-丙二醇合成路线 （共 39 条）
反应条件
1: 90 percent / (n-Bu)3SnH; AIBN / toluene / reflux 2: 87 percent / LAH / diethyl ether / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 16 p. 2769 - 2772
反应条件
1: O3 / CH2Cl2 / -78 °C 2: NaBH4 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 51 p. 9253 - 9254
反应条件
1: base 2: O3 / CH2Cl2 / -78 °C 3: NaBH4 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 51 p. 9253 - 9254
反应条件
1: 82 percent / tri-n-butyltin hydride, AIBN / toluene / 0.67 h / Heating 2: LiAlH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 25 p. 2857 - 2860
反应条件
1: With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane 2: With trimethylsilyl trifluoromethanesulfonate; (-)-menthone 3: With hydrogenchloride in methanol
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2178 - 2189
反应条件
sodium hydroxide; borane-THF; dihydrogen peroxide 1.) CH2Cl2, -45 deg C; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 34, # 50 p. 8155 - 8156
反应条件
1: With C15H19N2O2(1+)*F6P(1-); (S)-bis{4-[(dioctylamino)methyl]phenyl}(pyrrolidin-2-yl)methanol T=25°C; 96 h; Green chemistry; 2: With sodium tetrahydroborate in methanol T=0°C; 0.5 h; Green chemistry; Catalytic behavior; Overall yield = 35 percent; Overall yield = 21.3 mg; enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 78, # 6 p. 2693 - 2696
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 30, # 50 p. 7121 - 7124
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere 3: hydrazine hydrate / ethanol / 3 h / Reflux View Scheme
参考文献
Sasikumar; Nikalje, Milind D.
Synthetic Communications, 2012 , vol. 42, # 20 p. 3061 - 3067
