[2-(1H-吲哚-3-基)乙基]氨基甲酸叔丁酯合成路线 （共 13 条）
反应条件
1: 219.0 mg / NaOH; Bu4NHSO4 / CH2Cl2 / 6 h / 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C 3: 243 mg / triethylamine / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Song, Hao; Yang, Jun; Chen, Wei; Qin, Yong
Organic Letters, 2006 , vol. 8, # 26 p. 6011 - 6014
反应条件
1: 96 percent / KH / tetrahydrofuran; various solvent(s) / -50 - 20 °C 2: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Benson, Scott C.; Lee, Lily; Yang, Lydie; Snyder, John K.
Tetrahedron, 2000 , vol. 56, # 9 p. 1165 - 1180
反应条件
1: 219.0 mg / NaOH; Bu4NHSO4 / CH2Cl2 / 6 h / 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Song, Hao; Yang, Jun; Chen, Wei; Qin, Yong
Organic Letters, 2006 , vol. 8, # 26 p. 6011 - 6014
反应条件
in various solvent(s) T=150°C; 1 h; microwave irradiation;
参考文献
F. Hoffmann-La Roche AG
Patent: EP2070899 A1, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
triethylamine in 1,4-dioxane
1 h;
参考文献
Jahani, Fatemeh; Tajbakhsh, Mahmood; Khaksar, Samad; Azizi, Mohamad Reza
Monatshefte fur Chemie, 2011 , vol. 142, # 10 p. 1035 - 1043
反应条件
hydrogenchloride in dichloromethane; water
T=0 - 25°C; 2 h; Inert atmosphere;
参考文献
Nicolaou; Krasovskiy, Arkady; Trepanier, Vincent E.; Chen, David Y.-K.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 22 p. 4217 - 4220
反应条件
hydrogenchloride in dichloromethane; water
T=0 - 25°C; 2 h;
参考文献
Nicolaou, K. C.; Krasovskiy, Arkady; Majumder, Utpal; Trepanier, Vincent E.; Chen, David Y.-K.
Journal of the American Chemical Society, 2009 , vol. 131, p. 3690 - 3699
反应条件
triethylamine in 1,4-dioxane
T=20°C; 24 h;
参考文献
Roy, Sudipta; Haque, Sakhina; Gribble, Gordon W.
Synthesis, 2006 , # 23 p. 3948 - 3954
反应条件
zinc(II) chloride in water; acetonitrile
T=20°C; 1 h;
参考文献
Arifuddin, M.; Lakshmikant, N.; Rajasekar, N.; Shinde, D. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012 , vol. 51, # 8 p. 1168 - 1172,5
反应条件
sodium tetrahydroborate; nickel dichloride in methanol
T=0 - 20°C; 15 h;
参考文献
Caddick, Stephen; Judd, Duncan B.; Lewis, Alexandra K. De K.; Reich, Melanie T.; Williams, Meredith R. V.
Tetrahedron, 2003 , vol. 59, # 29 p. 5417 - 5423
