(E)-4-氧代壬-2-烯醛合成路线 （共 17 条）
反应条件
1: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 5 min 2: 70 percent / sodium borohydride / methanol / 0.08 h / 0 °C View Scheme
参考文献
Gunn, Bruce P.
Heterocycles, 1985 , vol. 23, # 12 p. 3061 - 3067
反应条件
hydrogenchloride in water; acetonitrile T=37°C; 0.166667 h;
参考文献
Saito, Fumie; Iwamoto, Satoshi; Yamauchi, Ryo
Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 1 p. 168 - 174
反应条件
1: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 5 min 2: 70 percent / sodium borohydride / methanol / 0.08 h / 0 °C 3: 100 percent / lithium hydroxide / propan-2-ol; H2O / 1.5 h / Ambient temperature View Scheme
参考文献
Gunn, Bruce P.
Heterocycles, 1985 , vol. 23, # 12 p. 3061 - 3067
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 1 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1935879 A1, 2008 ;
Location in patent: Page/Page column 191 ;
反应条件
hydrogenchloride in acetone
Hydrolysis; 4 h;
参考文献
Xu, Guozhang; Liu, Yahua; Sayre, Lawrence M.
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 5732 - 5745
反应条件
water; mercury dichloride in acetonitrile
24 h; Ambient temperature;
参考文献
Comasseto, J. V.; Brandt, C. A.
Synthesis, 1987 , # 2 p. 146 - 149
反应条件
ferrous iron; nicotinamide adenine dinucleotide; 1,3-DNP; E. coli nitroreductase in phosphate buffer
T=37°C; pH=7; 1 h;
参考文献
Chiron, Serge; Barbati, Stephane; De Meo, Michel; Botta, Alain
Environmental Toxicology, 2007 , vol. 22, # 2 p. 222 - 227
反应条件
2,4-dinitro-phenol; ferrous iron; nicotinamide adenine dinucleotide; E. coli nitroreductase in phosphate buffer
T=37°C; pH=7.0; 1 h;
参考文献
Chiron, Serge; Barbati, Stephane; De Meo, Michel; Botta, Alain
Environmental Toxicology, 2007 , vol. 22, # 2 p. 222 - 227
反应条件
1: 1.) n-BuLi / 1) THF, hexane, -20 deg C, 2 h; 2) THF, hexane, -20 deg C, 1 h, rt, 1 h
2: 70 percent / PCC / CH2Cl2 / 1) rt, 12 h; 2) reflux, 36 h
View Scheme
参考文献
Ballini; Bosica
Journal of Natural Products, 1998 , vol. 61, # 5 p. 673 - 674
反应条件
1: 68 percent / K2CO3 / tetrahydrofuran; 2-methyl-propan-2-ol / Ambient temperature
2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C; 2.) -78 deg C
3: 79 percent / HgCl2, H2O / acetonitrile / 24 h / Ambient temperature
View Scheme
参考文献
Comasseto, J. V.; Brandt, C. A.
Synthesis, 1987 , # 2 p. 146 - 149
