(E)-4-氧代壬-2-烯醛合成路线 （共 17 条）
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C; 2.) -78 deg C
2: 79 percent / HgCl2, H2O / acetonitrile / 24 h / Ambient temperature
View Scheme
参考文献
Comasseto, J. V.; Brandt, C. A.
Synthesis, 1987 , # 2 p. 146 - 149
反应条件
1: n-butyllithium / tetrahydrofuran
2: pyridine; N-bromosuccinmide / tetrahydrofuran; water; acetone / 7 h / -20 - 25 °C
View Scheme
参考文献
Arora, Jasbir S.; Oe, Tomoyuki; Blair, Ian A.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 5 p. 247 - 251
反应条件
1.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / -10 - 0 °C
1.2: 4 h / -15 - -10 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 6 h / -25 °C / Inert atmosphere
2.2: -5 °C / Inert atmosphere
3.1: manganese(IV) oxide / hexane / 24 h / Inert atmosphere
4.1: citric acid / water / 24 h
View Scheme
参考文献
Arora, Jasbir S.; Oe, Tomoyuki; Blair, Ian A.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 5 p. 247 - 251
反应条件
1: manganese(IV) oxide / hexane / 24 h / Inert atmosphere
2: citric acid / water / 24 h
View Scheme
参考文献
Arora, Jasbir S.; Oe, Tomoyuki; Blair, Ian A.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 5 p. 247 - 251
反应条件
bromine; iodine; sodium carbonate; toluene-4-sulfonic acid
Yield given. Multistep reaction;
参考文献
Gunn, Bruce P.
Heterocycles, 1985 , vol. 23, # 12 p. 3061 - 3067
反应条件
1: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 5 min
2: 70 percent / sodium borohydride / methanol / 0.08 h / 0 °C
View Scheme
参考文献
Gunn, Bruce P.
Heterocycles, 1985 , vol. 23, # 12 p. 3061 - 3067
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
T=20°C; 2 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1935879 A1, 2008 ;
Location in patent: Page/Page column 191 ;
