2-[[[3-甲基-4-(2,2,2三氟乙氧基)-2-吡啶]-甲基]硫基]-1H-苯并咪唑合成路线 （共 18 条）
反应条件
sodium hydroxide in methanol; water T=10 - 35°C; 4 h;
参考文献
WO2004/56803 A1, ;
Page 7,8 ;
反应条件
hydrogenchloride; sodium hydroxide; thionyl chloride in methanol; water
反应条件
sodium hydroxide in water Flow reactor;
参考文献
Organic Process Research and Development, , vol. 17, # 10 p. 1272 - 1276
参考文献
EP1681056 A1, ;
Page/Page column 9 ;
反应条件
1.1: pTsCl / toluene / 0.5 h / 50 °C 1.2: Et3N / toluene / 1.5 h / 65 °C 2.1: methanol / Heating View Scheme
参考文献
Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217
反应条件
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 3: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
thionyl chloride; sodium methylate 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
6-aza-5β,6β-epoxy-cholestane-based tetrafluoroborate salt in dichloromethane T=-70 - 20°C; 3 h;
参考文献
Del Rio; Wang; Achab; Bohe
Organic Letters, 2007 , vol. 9, # 12 p. 2265 - 2268
反应条件
1: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride; 2-mercaptobenzoimidazole With sodium hydroxide in water T=25 - 35°C; Inert atmosphere; 2: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]thio]-1H-benzimidazole With water; (+)-Weinsaeure-diethylester in dichloromethane T=55 - 60°C; 0.25 h; Inert atmosphere;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; VENKATESH, Mummadi
Patent: WO2010/95144 A2, 2010 ;
Location in patent: Page/Page column 27 ;
反应条件
(DHQD)2Pyr; dihydrogen peroxide; WO3 in tetrahydrofuran T=0°C; 50 h; Title compound not separated from byproducts;
参考文献
EMCURE PHARMACEUTICALS LIMITED
Patent: WO2008/152462 A1, 2008 ;
Location in patent: Page/Page column 19 ;
