2, 3-二甲基-4-(2,2,2-三氟乙氧基)吡啶-N-氧化物合成路线 （共 12 条）
反应条件
potassium tert-butylate T=50 - 60°C; 42 h;
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
2,2,2-trifluoroethanol T=50°C; 12 h;
参考文献
Archiv der Pharmazie, , vol. 346, # 12 p. 891 - 900
反应条件
1: dihydrogen peroxide; acetic acid / 24 h / |Reflux 2: nitric acid; sulfuric acid / 24 h / 90 °C 3: 2,2,2-trifluoroethanol / 12 h / 50 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 346, # 12 p. 891 - 900
反应条件
1: nitric acid; sulfuric acid / 24 h / 90 °C 2: 2,2,2-trifluoroethanol / 12 h / 50 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 346, # 12 p. 891 - 900
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1.1: pTsCl / toluene / 0.5 h / 50 °C 1.2: Et3N / toluene / 1.5 h / 65 °C 2.1: methanol / Heating View Scheme
参考文献
Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217
反应条件
sodium hydroxide; sulfuric acid; acetic anhydride 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h; Yield given. Multistep reaction;
参考文献
Ma, Chao; Wu, Anhui; Wu, Yongqi; Ren, Xuhong; Cheng, Maosheng
Archiv der Pharmazie, 2013 , vol. 346, # 12 p. 891 - 900
反应条件
1: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 2: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 3: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
1: With p-toluenesulfonyl chloride in toluene T=50°C; 0.5 h; 2: With triethylamine in toluene T=65°C; 1.5 h;
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
