2-羟甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶合成路线 （共 9 条）
反应条件
sodium hydroxide in methanol T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
sodium hydroxide; sulfuric acid; acetic anhydride 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
1.1: dihydrogen peroxide; acetic acid / 24 h / |Reflux 2.1: nitric acid; sulfuric acid / 24 h / 90 °C 3.1: 2,2,2-trifluoroethanol / 12 h / 50 °C 4.1: acetic anhydride; sulfuric acid / 5 h / 110 °C 4.2: 2 h / |Reflux View Scheme
参考文献
Archiv der Pharmazie, , vol. 346, # 12 p. 891 - 900
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 90 °C 2.1: 2,2,2-trifluoroethanol / 12 h / 50 °C 3.1: acetic anhydride; sulfuric acid / 5 h / 110 °C 3.2: 2 h / |Reflux View Scheme
参考文献
Archiv der Pharmazie, , vol. 346, # 12 p. 891 - 900
反应条件
hydrogenchloride; sodium hydroxide; thionyl chloride in methanol; water
反应条件
thionyl chloride; sodium methylate 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 10 p. 2853 - 2858
反应条件
1: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 2: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme
参考文献
Kubo; Oda; Kaneko; Satoh; Nohara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2853 - 2858
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
