反应条件
1: 100 percent / triton B / tetrahydrofuran; 2-methyl-propan-2-ol / 48 h / Ambient temperature 2: 81 percent / zinc, conc. HCl / ethanol / 15 h / Heating 3: 1.) osmium tetraoxide, 2.) sodium metaperiodate / 1.) THF, water, 0 deg C, 5 min, 2.) THF, water, 1.5 h 4: 100 percent / p-toluenesulfonic acid (PTSA) / CH2Cl2 / 3 h / Heating 5: 90 percent / 70 percent sodium bis(2-methoxyethoxy)aluminum hydride in toluene / benzene / Heating 6: 98 percent / 1,3-dicyclohexylcarbodimide (DCC) / CH2Cl2 / 48 h / Ambient temperature 7: 92 percent / acetic acid; H2O / 1 h / Heating 8: 100 percent / sodium metaperiodate / methanol; H2O / Ambient temperature 9: 100 percent / sodium borohydride / ethanol / 3 h / Ambient temperature 10: 92 percent / pyridine / Ambient temperature 11: 100 percent / sodium metaperiodate / methanol; H2O / Ambient temperature 12: 85 percent / trifluoroacetic anhydride (TFAA) / CH2Cl2 / 576 h / Ambient temperature 13: 100 percent / Raney nickel (W-2) / acetone / 1 h / Heating 14: 1.04 g / K2CO3 / methanol; CH2Cl2 / 0.5 h / Ambient temperature 15: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) triethylamine / 1.) dichloromethane, -60 deg C, 40 min, 2.) dichloromethane, from -60 deg C to RT, 60 min 16: 78 percent / KOH, iodobenzene diacetate / methanol / 3 h / 0 °C 17: 83 mg / 70 percent sodium bis(2-methoxyethoxy)aluminum hydride in toluene / benzene / Heating 18: 85 percent / p-toluenesulfonic acid (PTSA) monohydrate / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Ikeda; Okano; Kosaka; Kido; Ishibashi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 2 p. 276 - 281
