5-(三氟甲基)-3-((三甲基甲硅烷基)乙炔)-吡啶-2-胺合成路线 （共 2 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
WO2008/79346 A1, ;
Page/Page column 58; 59 ;
WO 2008/079346 A1
反应条件
1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=80 - 100°C; 2: With water; sodium chloride T=10 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 59 ;
WO 2008/079346 A1
