5-三氟甲基-7-N-杂吲哚合成路线 （共 2 条）
反应条件
1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=80 - 100°C; 2: With water; sodium chloride T=10 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 59 ;
WO 2008/079346 A1
反应条件
water; acetic acid 2.5 h; Reflux;
参考文献
sanofi-aventis
Patent: US2009/253679 A1, 2009 ;
Location in patent: Page/Page column 41-42 ;
