1: With bromine in chloroform T=0 - 20°C; 2 h; 2: With sodium hydrogencarbonate; sodium thiosulfate in chloroform; water pH=12; Alkaline aqueous solution;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/79346 A1, 2008 ;
Location in patent: Page/Page column 149 ;
WO 2008/079346 A1