甲基 2-(3-羟基-1-丙炔)苯甲酸合成路线 （共 7 条）
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in acetonitrile 3 h; Inert atmosphereReflux;
参考文献
GLAXOSMITHKLINE LLC; DE LA ROSA, Martha Alicia; HAYDAR, Simon, N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann
Patent: WO2012/102985 A1, 2012 ;
Location in patent: Page/Page column 94 ;
反应条件
diisobutylaluminium hydride; triphenylphosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=20°C; Cycloaddition;
参考文献
Tetrahedron Letters, , vol. 40, # 28 p. 5231 - 5234
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in N,N-dimethyl-formamide T=60°C; Substitution;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 8 p. 1508 - 1518
反应条件
1: TEA / tetrahydrofuran / -78 - 20 °C 2: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 8 p. 1508 - 1518
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethylamine Sonogashira coupling; 3 h; Heating;
参考文献
Tetrahedron Letters, , vol. 43, # 50 p. 9187 - 9189
反应条件
manganese(IV) oxide; potassium hydroxide in diethyl ether T=20°C; 0.5 h;
参考文献
Bumagin, N. A.; Ponomarev, A. B.; Beletskaya, I. P.
Doklady Chemistry, 1985 , vol. 283, p. 212 - 214
Dokl. Akad. Nauk SSSR Ser. Khim., 1985 , vol. 283, # 3 p. 630 - 633
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
Catalytic hydrogenation; P=1551.49 Torr; 1 h;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87751 A2, 2005 ;
Location in patent: Page/Page column 242-243 ;
WO 2005/087751 A2
