2,3-二氢-1-甲基-3-氧代-1H-吡唑-4-羧酸乙酯合成路线 （共 5 条）
反应条件
hydrogen bromide; acetic acid 4 h; Heating;
参考文献
Cottineau, Bertrand; Toto, Patrick; Marot, Christophe; Pipaud, Aline; Chenault, Jacques
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2105 - 2108
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C 1.2: 68 percent / tetrahydrofuran / 2 h / 20 °C 2.1: 90 percent / HBr; glacial AcOH / 4 h / Heating View Scheme
参考文献
Cottineau, Bertrand; Toto, Patrick; Marot, Christophe; Pipaud, Aline; Chenault, Jacques
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2105 - 2108
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=50°C;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2003/99793 A1, 2003 ;
Location in patent: Page 136 ;
反应条件
1: ethyl 3-hydroxy-1-methyl-1H-pyrazole-4-carboxylate With silica gel; diazomethyl-trimethyl-silane in hexane; dichloromethane T=20°C; 72 h; 2: methanol in hexane; dichloromethane
参考文献
WO2005/42492 A1, ;
Page/Page column 44 ;
反应条件
in methanol; hexane; dichloromethane; water; ethyl acetate
