N-(4-溴苄基)-2,2-二甲氧基乙胺合成路线 （共 4 条）
反应条件
1: With acetic acid in methanol T=20°C; 1 h; 2: With methanol; sodium tetrahydroborate T=0 - 20°C; 10 h;
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei
Patent: WO2011/103196 A1, 2011 ;
Location in patent: Page/Page column 76 ;
WO 2011/103196 A1
反应条件
sodium tetrahydroborate in ethanol 24 h; Ambient temperature;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 0.33 h / Heating 2: sodium borohydride / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: With chlorosulfonic acid in dichloromethane T=-20 - 45°C; 10 h; 2: With sodium hydrogencarbonate in dichloromethane; water Cooling with ice;
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei
Patent: WO2011/103196 A1, 2011 ;
Location in patent: Page/Page column 76 ;
WO 2011/103196 A1
