1: 38 percent / Pd(PPh3)4, 2M aq. Na2CO3 / 1,2-dimethoxy-ethane / 12 h / 100 °C
2: 61 percent / methanesulfonic acid / 1 h / 110 °C
3: 37 percent / boron trifluoride-dimethyl sulfide / CH2Cl2 / 48 h / Ambient temperature
View Scheme
参考文献
Kym, Philip R.; Hummert, Kim L.; Nilsson, Anna G.; Lubin, Martin; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4897 - 4904
potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0) in water
T=65°C; 2 h;
参考文献
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Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6640 - 6658
Lee, Hyosung; Park, Ki Duk; Yang, Xiao-Fang; Dustrude, Erik T.; Wilson, Sarah M.; Khanna, Rajesh; Kohn, Harold
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