4-[3-(4-哌啶基)-1H-吡唑-5-基]-苯甲醚合成路线 （共 5 条）
反应条件
potassium hydroxide; hydrazine hydrate in ethylene glycol T=165 - 170°C; 7 h;
参考文献
Turchin, K. F.; Yanina, A. D.; Filipenko, T. Ya.; Mikhlina, E. E.; Sheinker, Yu. N.; Yakhtonov, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1039 - 1048
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1248 - 1256
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3693 - 3696
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 96 percent / 1,1'-carbonylbis-1H-imidazole / tetrahydrofuran / 12 h / 20 °C 2.1: hydrazine hydrate / ethanol / 12 h / Heating 3.1: CF3CO2H / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3693 - 3696
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 96 percent / 1,1'-carbonylbis-1H-imidazole / tetrahydrofuran / 12 h / 20 °C 2.1: hydrazine hydrate / ethanol / 12 h / Heating 3.1: CF3CO2H / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3693 - 3696
反应条件
1: hydrazine hydrate / ethanol / 12 h / Heating 2: CF3CO2H / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3693 - 3696
