2-(苄氧基)-1-溴-3-氟苯合成路线 （共 2 条）
反应条件
potassium carbonate in acetonitrile T=150°C; 0.25 h; Microwave irradiation;
参考文献
JANSSEN PHARMACEUTICALS, INC.; ANDRES-GIL, Jose, Ignacio; ALCAZAR-VACA, Manuel, Jesus; CID-NUNEZ, Jose, Maria; TRABANCO-SUAREZ, Andres, Avelino; BORMANS, Guy, Maurits R.; CELEN, Sofie, Jeanne, Leopoldine; KOOLE, Michel
Patent: WO2012/62752 A1, 2012 ;
Location in patent: Page/Page column 35-36 ;
WO 2012/062752 A1
反应条件
1: benzyl alcohol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 3-bromo-1,2-difluorobenzene in tetrahydrofuran T=20°C; 17 h; Further stages. Title compound not separated from byproducts.;
参考文献
Dirr, Ronan; Anthaume, Cyril; Desaubry, Laurent
Tetrahedron Letters, 2008 , vol. 49, # 31 p. 4588 - 4590
