2-(二异丙基羰基)苯硼酸合成路线 （共 17 条）
反应条件
1: N,N-di-iso-propylbenzamide With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; Metallation; Substitution; Hydrolysis; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - 20°C; 3: With hydrogenchloride; ammonium chloride in tetrahydrofuran; cyclohexane pH=5 - 6;
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
1: With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 1.25 h; 2: With boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - 20°C; Further stages.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 9 p. 1854 - 1855
反应条件
1.1: 100 percent / Et3N / diethyl ether / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1.25 h / -78 °C 2.2: B(OMe)3 / tetrahydrofuran; cyclohexane / -78 - 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 9 p. 1854 - 1855
反应条件
1.1: 100 percent / Et3N / diethyl ether / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1.25 h / -78 °C 2.2: B(OMe)3 / tetrahydrofuran; cyclohexane / -78 - 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 9 p. 1854 - 1855
反应条件
hydrogenchloride in water
参考文献
WO2004/113351 A2, ;
Page 36 ;
反应条件
1: 81 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 2: 98 percent / LDA / tetrahydrofuran / 20 °C View Scheme
参考文献
Fu, J.-m.; Sharp, M.J.; Snieckus, V.
Tetrahedron Letters, 1988 , vol. 29, # 43 p. 5459 - 5462
反应条件
1: 73 percent / 2 M aq.Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 2: 1) BBr3, 2) glacial HOAc / 1) CH2Cl2, overnight, 2) reflux, 18 h View Scheme
参考文献
Alo, B. I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3763 - 3768
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene
Heating;
参考文献
Sharp, M.J.; Snieckus, V.
Tetrahedron Letters, 1985 , vol. 26, # 49 p. 5997 - 6000
反应条件
1: 57 percent / aq. Na2CO3; [Pd(PPh3)4] / 1,2-dimethoxy-ethane / 18 h / 83 °C
2: 60 percent / concd. HCl / methanol / 24 h / Heating
View Scheme
参考文献
Rocca, P.; Cochennec, C.; Marsais, F.; Thomas-dit-Dumont, L.; Mallet, M.; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7832 - 7838
