(R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 14 条）
反应条件
hydrogenchloride T=100°C; 4 h;
参考文献
Shinkai, Hisashi; Toi, Koji; Kumashiro, Izumi; Seto, Yoshiko; Fukuma, Mariko; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2092 - 2097
反应条件
sodium hydroxide in water 15 h; Ambient temperature;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
sodium hydroxide in methanol 6 h; Ambient temperature;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
water Hydrolysis; 12 h; Heating;
参考文献
Guillena; Najera
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7310 - 7322
反应条件
1: NaOMe / 4 h / Heating 2: 6 N aq. HCl / 4 h / Heating 3: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 4: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1157 - 1160
反应条件
1: 6 N aq. HCl / 4 h / Heating 2: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 3: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1157 - 1160
反应条件
1: 75 percent / NaOMe / 4 h / Heating 2: 6 N aq. HCl / 4 h / Heating 3: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 4: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1157 - 1160
反应条件
1: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 2: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1157 - 1160
反应条件
1: 86 percent / 6 N aq. HCl / 4 h / Heating 2: 76 percent / p-TsOH*H2O / toluene / 30 h / Heating 3: 90 percent / NaOH / methanol / 6 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1157 - 1160
反应条件
water Hydrolysis; epimerization; 12 h; Heating; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 22 p. 7310 - 7322
