(R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸合成路线 (共 14 条)
反应条件
(+/-)-camphor-10-sulfonic acid; acetic acid T=120°C; other carboxylic acid; Rate constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 64, # 12 p. 3729 - 3731
反应条件
toluene-4-sulfonic acid in benzene Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/72086 A2, 2004 ;
Location in patent: Page 182 ;
反应条件
1.1: aq. NaOH / dioxane / 20 °C 2.1: aq. Cs2CO3 / methanol / 0.17 h / 20 °C 2.2: dimethylformamide / 12 h / 20 °C 3.1: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Charton, Julie; Gassiot, Amaury Cazenave; Girault-Mizzi, Sophie; Debreu-Fontaine, Marie-Ange; Melnyk, Patricia; Sergheraert, Christian
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4833 - 4837
反应条件
1: (3R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid With N,O-bis-(trimethylsilyl)-acetamide in acetonitrile
1.5 h; Heating / reflux;
2: (4'-chlorosulfonyl-biphenyl-4-yl)carbamic acid isopropylester in acetonitrile
2.5 h; Heating / reflux;
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2005/47263 A1, 2005 ;
Location in patent: Page/Page column 12; 13 ;