17-羟基-7-甲基-D-高雌甾-4,16-二烯-3-酮合成路线 （共 5 条）
反应条件
hydrogenchloride in methanol; water 0.333333 h; Heating; Yield given;
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
1: 14.45 g / ZnI2 / CHCl3 / 19 h / 22 °C 2: 78 percent / LAH / tetrahydrofuran; diethyl ether / 3 h / 23 °C 3: 1.) acetic acid, NaNO2 / 1.) H2O, 0 deg C, 2.) 22 deg C, 18 h 4: 1.) phenylselenyl chloride, 2.) H2O2 / 1.) ethyl acetate, 23 deg C, 3 h, 2.) 1 h 5: 100 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.75 h / 0 °C 6: 87 percent / NH3, Li / tetrahydrofuran / 0.75 h / -78 °C 7: HCl / H2O; methanol / 0.33 h / Heating View Scheme
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
1: 87 percent / NH3, Li / tetrahydrofuran / 0.75 h / -78 °C 2: HCl / H2O; methanol / 0.33 h / Heating View Scheme
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
1: 1.) acetic acid, NaNO2 / 1.) H2O, 0 deg C, 2.) 22 deg C, 18 h 2: 1.) phenylselenyl chloride, 2.) H2O2 / 1.) ethyl acetate, 23 deg C, 3 h, 2.) 1 h 3: 100 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.75 h / 0 °C 4: 87 percent / NH3, Li / tetrahydrofuran / 0.75 h / -78 °C 5: HCl / H2O; methanol / 0.33 h / Heating View Scheme
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
反应条件
1: 78 percent / LAH / tetrahydrofuran; diethyl ether / 3 h / 23 °C 2: 1.) acetic acid, NaNO2 / 1.) H2O, 0 deg C, 2.) 22 deg C, 18 h 3: 1.) phenylselenyl chloride, 2.) H2O2 / 1.) ethyl acetate, 23 deg C, 3 h, 2.) 1 h 4: 100 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.75 h / 0 °C 5: 87 percent / NH3, Li / tetrahydrofuran / 0.75 h / -78 °C 6: HCl / H2O; methanol / 0.33 h / Heating View Scheme
参考文献
Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M.
Steroids, 1990 , vol. 55, # 2 p. 59 - 64
