3-(3,4-二氯-苯基)-二氢-呋喃-2-酮合成路线 （共 6 条）
反应条件
1: With sodium hydride in N,N-dimethyl-formamide T=20°C; 17 h; 2: With hydrogenchloride; methanol in 1,4-dioxane T=20°C; 16 h;
参考文献
WO2008/81012 A1, ;
Page/Page column 43-44 ;
WO 2008/081012 A1
反应条件
hydrogenchloride; PTSA in tetrahydrofuran; methanol
参考文献
US5840725 A1, ;
US 5840725 A
US5696267 A1, ;
US 5696267 A
反应条件
sulfuric acid in ethanol Cyclization; 24 h; reflux;
参考文献
Synthetic Communications, , vol. 28, # 18 p. 3305 - 3315
反应条件
1: 98 percent / piperidine; benzoic acid / benzene / refluxing overnight under an argon atmosphere with Dean-Stark trap 2: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C 3: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h 4: 65 percent / sulfuric acid / aq. ethanol / 24 h / reflux View Scheme
参考文献
Synthetic Communications, , vol. 28, # 18 p. 3305 - 3315
反应条件
1: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h 2: 65 percent / sulfuric acid / aq. ethanol / 24 h / reflux View Scheme
参考文献
Synthetic Communications, , vol. 28, # 18 p. 3305 - 3315
反应条件
1: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C 2: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h 3: 65 percent / sulfuric acid / aq. ethanol / 24 h / reflux View Scheme
参考文献
Synthetic Communications, , vol. 28, # 18 p. 3305 - 3315
