5-硝基-2,3,4,5-四氟苯甲酰氯合成路线 （共 5 条）
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Warner-Lambert Company
Patent: US4822801 A1, 1989 ;
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 16 h;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 2: 95 percent / Ac2O / 3 h / Heating 3: 2-methyl-propan-2-ol / 3.5 h / 45 °C 4: t-BuOK / 6 h / 60 °C 5: 100 percent / H2 / RaNi / tetrahydrofuran; ethanol / 12 h / 1034.3 Torr 6: 100 percent / 6 M HCl / 2 h / Heating View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 2: 95 percent / Ac2O / 3 h / Heating 3: 2-methyl-propan-2-ol / 3.5 h / 45 °C 4: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h
2: 95 percent / Ac2O / 3 h / Heating
3: 2-methyl-propan-2-ol / 3.5 h / 45 °C
4: t-BuOK / 6 h / 60 °C
5: 100 percent / H2 / RaNi / tetrahydrofuran; ethanol / 12 h / 1034.3 Torr
View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
