1-环丙基-5-硝基-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯合成路线 （共 8 条）
反应条件
potassium tert-butylate 1.) Ac2O, 3.) t-BuOH; Yield given. Multistep reaction;
参考文献
Warner-Lambert Company
Patent: US4822801 A1, 1989 ;
反应条件
1: oxalyl chloride, DMF / CH2Cl2 / 16 h 2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 3: 95 percent / Ac2O / 3 h / Heating 4: 2-methyl-propan-2-ol / 3.5 h / 45 °C 5: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 2: 95 percent / Ac2O / 3 h / Heating 3: 2-methyl-propan-2-ol / 3.5 h / 45 °C 4: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 95 percent / Ac2O / 3 h / Heating 2: 2-methyl-propan-2-ol / 3.5 h / 45 °C 3: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 2-methyl-propan-2-ol / 3.5 h / 45 °C 2: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: 1.) H2, 2.) HCl / 1.) RaNi 2: 75 percent / acetonitrile / Heating View Scheme
参考文献
Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, p. 503 - 506
反应条件
hydrogenchloride; hydrogen; 1.) RaNi Yield given. Multistep reaction;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
hydrogen; RaNi in tetrahydrofuran; ethanol
P=1034.3 Torr; 12 h;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
