2-(5-甲基-2-苯基-1,3-恶唑-4-基)-1-乙醇合成路线 （共 32 条）
反应条件
1: toluene; dioxane / Heating 2: LiAlH4 / diethyl ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 995 - 1010
反应条件
1: 91 percent / POCl3 / toluene / 2 h / Heating 2: 91 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 14 p. 2617 - 2626
反应条件
1: 18 percent / phosphorus oxychloride / toluene / 4 h / Heating 2: 78 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1853 - 1864
反应条件
1: KOH / tetrahydrofuran; H2O / Heating 2: 68 percent / BH3*SMe2 / tetrahydrofuran / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 937 - 941
反应条件
1: bromine / chloroform / 0 - 20 °C 2: toluene / Reflux 3: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 3639 - 3650
反应条件
1: tetrahydrofuran / 2.5 h / 20 °C / |Inert atmosphere; |Molecular sieve 2: [RhCl(η2:η2-cycloocta-1,5-diene)]2 / tetrahydrofuran / 20 °C / |Inert atmosphere 3: potassium carbonate; methanol / tetrahydrofuran / 5 h / |Inert atmosphere 4: neat (no solvent) / 0.25 h / 150 °C / |Inert atmosphere; |Microwave irradiation 5: Pd(OH)2/C; hydrogen / ethanol / 0.5 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4578 - 4585
反应条件
1: [RhCl(η2:η2-cycloocta-1,5-diene)]2 / tetrahydrofuran / 20 °C / |Inert atmosphere 2: potassium carbonate; methanol / tetrahydrofuran / 5 h / |Inert atmosphere 3: neat (no solvent) / 0.25 h / 150 °C / |Inert atmosphere; |Microwave irradiation 4: Pd(OH)2/C; hydrogen / ethanol / 0.5 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 4578 - 4585
反应条件
1: 99 percent / HCl / dioxane / 20 °C 2: 99 percent / POCl3 / CHCl3 / Heating 3: 95 percent / dimethylformamide / 80 °C 4: KOH / tetrahydrofuran; H2O / Heating 5: 68 percent / BH3*SMe2 / tetrahydrofuran / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 937 - 941
反应条件
1: HCl / acetic acid / 2 h / 0 - 5 °C 2: 0.559 g / zinc; AcOH / 0.5 h / 40 °C 3: 93 percent / LiAlH4 / diethyl ether / 1 h / 20 °C View Scheme
参考文献
Synthesis, , # 10 p. 1569 - 1571
反应条件
1: 80 percent / methyl nitrite; HCl / diethyl ether / 2 h / 20 °C 2: HCl / acetic acid / 2 h / 0 - 5 °C 3: 0.559 g / zinc; AcOH / 0.5 h / 40 °C 4: 93 percent / LiAlH4 / diethyl ether / 1 h / 20 °C View Scheme
参考文献
Synthesis, , # 10 p. 1569 - 1571
