(2,2-二甲基-[1,3]二氧杂烷-4-基)-羟基乙酸乙酯合成路线 （共 9 条）
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 0.25 h;
参考文献
Gessier, Francois; Tschamber, Theophile; Tarnus, Celine; Neuburger, Markus; Huber, Walter; Streith, Jacques
European Journal of Organic Chemistry, 2001 , # 21 p. 4111 - 4125
反应条件
1: 47 percent / NaH / dimethylformamide / 3 h
2: O3 / CH2Cl2 / -78 °C
View Scheme
参考文献
Metz; Schoop
Tetrahedron, 1993 , vol. 49, # 46 p. 10597 - 10608
反应条件
ozone in dichloromethane
T=-78°C;
参考文献
Metz; Schoop
Tetrahedron, 1993 , vol. 49, # 46 p. 10597 - 10608
反应条件
lithium aluminium tetrahydride; phosphate buffer; oxalyl dichloride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid
Multistep reaction;
参考文献
Dyer, Ulrich C.; Kishi, Yoshito
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3383 - 3384
反应条件
1: 55 percent / CH2Cl2 / 20 °C
2: 83 percent / Bu4NI; NaH / tetrahydrofuran / 20 °C
3: ozone / CH2Cl2 / -78 °C
View Scheme
参考文献
Fernandez; Martin-Zamora; Pareja; Lassaletta
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5201 - 5207
反应条件
1: 83 percent / AgO2; KI; 4A MS / toluene / 2 h / Heating
2: 97 percent / DIBAH / toluene / 0.25 h / -78 °C
View Scheme
参考文献
Gessier, Francois; Tschamber, Theophile; Tarnus, Celine; Neuburger, Markus; Huber, Walter; Streith, Jacques
European Journal of Organic Chemistry, 2001 , # 21 p. 4111 - 4125
反应条件
1: 1) (COCl)2, DMSO, 2) Et3N
2: MCPBA / CH2Cl2 / 3 h / phosphate buffer (pH 7)
3: LiAlH4 / diethyl ether / 1 h / 0 °C
4: 1) (COCl)2, DMSO, 2) Et3N
View Scheme
参考文献
Wang, Yuan; Babirad, Stefan A.; Kishi, Yoshito
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 468 - 481
反应条件
dimethylsulfide; ozone
Yield given;
参考文献
Kusakabe, Masato; Sato, Fumie
Chemistry Letters, 1986 , p. 1473 - 1476
反应条件
1: 1.) NaH / 1.) HMPA
2: O3, Me2S
View Scheme
参考文献
Kusakabe, Masato; Sato, Fumie
Chemistry Letters, 1986 , p. 1473 - 1476
