2-溴-4-氯苯乙酸异丙酯合成路线 （共 5 条）
反应条件
in 1,2-dichloro-ethane T=4 - 17°C;
参考文献
METABOLEX, INC.
Patent: WO2004/112774 A1, 2004 ;
Location in patent: Page/Page column 35; 40 -41 ;
反应条件
hydrogen bromide 3 h; Heating;
参考文献
Robert, A.; Jaguelin, S.; Guinamant, J. L.
Tetrahedron, 1986 , vol. 42, # 8 p. 2275 - 2282
反应条件
phosphorus tribromide in tetrahydrofuran
参考文献
Su, Yijin; Zhang, Liangren; Jiao, Ning
Organic Letters, 2011 , vol. 13, # 9 p. 2168 - 2171
反应条件
1: 98 percent / 2.5 N sodium hypochlorite, 2 N sulfuric acid / acetonitrile / 0.5 h / Ambient temperature 2: 85 percent / 48percent hydrobromic acid / 3 h / Heating View Scheme
参考文献
Robert, A.; Jaguelin, S.; Guinamant, J. L.
Tetrahedron, 1986 , vol. 42, # 8 p. 2275 - 2282
反应条件
1: 96 percent / piperidine / dioxane / 0.5 h / Ambient temperature 2: 98 percent / 2.5 N sodium hypochlorite, 2 N sulfuric acid / acetonitrile / 0.5 h / Ambient temperature 3: 85 percent / 48percent hydrobromic acid / 3 h / Heating View Scheme
参考文献
Robert, A.; Jaguelin, S.; Guinamant, J. L.
Tetrahedron, 1986 , vol. 42, # 8 p. 2275 - 2282
