2,3,4-(三甲氧基)溴苯合成路线 （共 31 条）
反应条件
1: 18 g / CuCl / dimethylformamide / 9 h / 110 °C 2: 90 percent / HCl / hexane / 20 °C 3: 94 percent / magnesium; ethanol / 2 h / 40 - 45 °C View Scheme
参考文献
Yang, Jian; Weng, Lingling; Zheng, Hu
Synthetic Communications, 2006 , vol. 36, # 16 p. 2401 - 2405
参考文献
Baker; Kirby; Montgomery
Journal of the Chemical Society, 1932 , p. 2876,2878
反应条件
1: With tert.-butyl lithium in tetrahydrofuran T=-80°C; 0.166667 h; Schlenk techniqueInert atmosphere; 2: With methanol in tetrahydrofuran T=-75°C; Inert atmosphereSchlenk technique;
参考文献
Waldmann, Christopher; Schober, Otmar; Haufe, Guenter; Kopka, Klaus
Organic Letters, 2013 , vol. 15, # 12 p. 2954 - 2957
反应条件
1: 73 percent / 2 M aq.Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 2: 1) BBr3, 2) glacial HOAc / 1) CH2Cl2, overnight, 2) reflux, 18 h View Scheme
参考文献
Alo, B. I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3763 - 3768
参考文献
Journal of the Chemical Society, , p. 2876,2878
反应条件
diethylene glycol monoethyl ether; sodium amide in ethylene glycol dimethyl ether 1.) 45 deg C, 2 h, 2.) -10 deg C, 2 h, 3.) -30 deg C, 4.5 h;
参考文献
Synthetic Communications, , vol. 19, # 19 p. 3323 - 3330
反应条件
sodium amide 1.) liquid ammonia, 5 min, 2.) liquid ammonia, 15 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 52, # 12 p. 2619 - 2622
反应条件
1: With tert.-butyl lithium in diethyl ether T=-95°C; 0.5 h; 2: With tri-isopropoxy-borane in diethyl ether T=-95°C; 0.333333 h; 3: With silica gel
参考文献
Synthetic Communications, , vol. 35, # 15 p. 2005 - 2016
反应条件
iodine; mercury(II) oxide in dichloromethane 72 h; Ambient temperature;
参考文献
Orito; Hatakeyama; Takeo; Suginome
Synthesis, 1995 , # 10 p. 1273 - 1277
反应条件
1: 74 percent / 2 M aq.Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 2: 1) BBr3, 2) glacial HOAc / 1) CH2Cl2, overnight, 2) reflux, 22 h View Scheme
参考文献
Alo, B. I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3763 - 3768
