4-氨基-1-[(2R,4R,5R)-3,3-二氟-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮盐酸盐合成路线 （共 6 条）
反应条件
ammonia in water Resolution of racemate;
参考文献
EP2180005 A1, ;
Page/Page column 8 ;
反应条件
Dithiothreitol; potassium chloride; adenosine 5'-triphosphoric acid; magnesium chloride; deoxycytidine kinase; BSA in water T=37°C; pH=7.6; 0.75 h; Tris bufferEnzymatic reaction;
参考文献
Lohman, Gregory J.S.; Stubbe, Joanne
Biochemistry, 2010 , vol. 49, # 7 p. 1404 - 1417
反应条件
hydrogenchloride in water; isopropyl alcohol T=-4 - 60°C; 6.5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2007/117760 A2, 2007 ;
Location in patent: Page/Page column 21 ;
反应条件
hydrogenchloride in 1,4-dioxane; water T=10 - 68°C; 1.5 h; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED
Patent: WO2007/49294 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
water; acetic acid 24 h; Heating;
参考文献
Hertel; Kroin; Misner; Tustin
Journal of Organic Chemistry, 1988 , vol. 53, # 11 p. 2406 - 2409
反应条件
hydrogenchloride in water; isopropyl alcohol T=-4 - 60°C; 6.5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2007/117760 A2, 2007 ;
Location in patent: Page/Page column 21 ;
