9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤合成路线 （共 18 条）
反应条件
hydrogenchloride; Tris buffer; adenosine deaminase in water T=20°C; pH=7.0; 1.5 h; Acidic aqueous solutionEnzymatic reaction;
参考文献
Mackman, Richard L.; Lin, Kuei-Ying; Boojamra, Constantine G.; Hui, Hon; Douglas, Janet; Grant, Deborah; Petrakovsky, Oleg; Prasad, Vidya; Ray, Adrian S.; Cihlar, Tomas
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1116 - 1119
反应条件
sodium hydroxide in 1,4-dioxane T=100°C; 1 h;
参考文献
Borthwick; Kirk; Biggadike; Exall; Butt; Roberts; Knight; Coates; Ryan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 907 - 914
反应条件
1.1: hexamethyldisilazane / 3 h / Heating 2.1: 35 percent / TMSOTf / acetonitrile / 0.33 h / Heating 3.1: LiN3 / ethanol / 2 h / Heating 3.2: benzoyl chloride / pyridine / 18 h / 20 °C 4.1: SnCl2 / CH2Cl2; methanol 5.1: 0.47 g / NH3 / methanol / 24 h / 20 °C 6.1: 0.45 g / adenosine deaminase E.C. 3.5.4.4 a / H2O / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 10-12 p. 1861 - 1884
反应条件
1: 4A molecular sieves / 1,2-dichloro-ethane / 16 h / Heating 2: 72 percent / aq. NaN3 / ethanol / 0.5 h / Heating 3: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr 4: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 5: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2389 - 2392
反应条件
1: 72 percent / aq. NaN3 / ethanol / 0.5 h / Heating 2: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr 3: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 4: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2389 - 2392
反应条件
1: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr 2: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 3: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2389 - 2392
反应条件
sodium methylate; 2-hydroxyethanethiol in methanol 3 h; Heating;
参考文献
Chu; Matulic-Adamic; Huang; Chou; Burchenal; Fox; Watanabe
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 2 p. 336 - 339
反应条件
1: 52 percent / CCl4 / 72 h / 77 °C 2: 67 percent / ammonia / methanol / 6 h / 150 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 5-8 p. 1339 - 1342
反应条件
1: 27 percent 2: sodium hydroxide / H2O View Scheme
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 10 p. 656 - 658
反应条件
1: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 2: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2389 - 2392
