9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤合成路线 （共 18 条）
反应条件
1: ammonium sulfate / 1.5 h / Heating 2: 1.) Hg(CN)2 / 1.) C6H6, reflux, 30 min, 2.) reflux, 3.4 h 3: 1 M Bu4NF / CH2Cl2; tetrahydrofuran / 0.25 h 4: 20 percent / 0.5 N aq. NaOH / dioxane / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 3 p. 907 - 914
反应条件
1: 40 percent / 2,4,6-collidine, AgNO3 / dimethylformamide / Ambient temperature 2: 43.5 percent / DAST, pyridine / CH2Cl2 / Ambient temperature; other substrates 3: 95 percent / DBU, pyridine / 15 h / Ambient temperature 4: 91 percent / CF3COOH / CHCl3 / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 28 p. 7315 - 7321
反应条件
1: 1.) Me3SiCl, Et3N; 2.) Hg(CN)2 / 1.) PhH, 40 h; 2.) PhH, reflux. 4 h 2: 67 percent / 2-mercaptoethanol (HSCH2CH2OH), 1M NaOMe / methanol / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 336 - 339
反应条件
1.1: 35 percent / TMSOTf / acetonitrile / 0.33 h / Heating 2.1: LiN3 / ethanol / 2 h / Heating 2.2: benzoyl chloride / pyridine / 18 h / 20 °C 3.1: SnCl2 / CH2Cl2; methanol 4.1: 0.47 g / NH3 / methanol / 24 h / 20 °C 5.1: 0.45 g / adenosine deaminase E.C. 3.5.4.4 a / H2O / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 10-12 p. 1861 - 1884
反应条件
1.1: 35 percent / TMSOTf / acetonitrile / 0.33 h / Heating 2.1: LiN3 / ethanol / 2 h / Heating 2.2: benzoyl chloride / pyridine / 18 h / 20 °C 3.1: SnCl2 / CH2Cl2; methanol 4.1: 0.47 g / NH3 / methanol / 24 h / 20 °C 5.1: 0.45 g / adenosine deaminase E.C. 3.5.4.4 a / H2O / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 10-12 p. 1861 - 1884
反应条件
1.1: LiN3 / ethanol / 2 h / Heating 1.2: benzoyl chloride / pyridine / 18 h / 20 °C 2.1: SnCl2 / CH2Cl2; methanol 3.1: 0.47 g / NH3 / methanol / 24 h / 20 °C 4.1: 0.45 g / adenosine deaminase E.C. 3.5.4.4 a / H2O / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 10-12 p. 1861 - 1884
反应条件
1: SnCl2 / CH2Cl2; methanol 2: 0.47 g / NH3 / methanol / 24 h / 20 °C 3: 0.45 g / adenosine deaminase E.C. 3.5.4.4 a / H2O / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 10-12 p. 1861 - 1884
参考文献
Gilead Sciences, Inc.
Patent: US5672697 A1, 1997 ;
